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126 The lactylation of EGR1 at K364 facilitates its interaction with importin-, in turn promoting its nuclear localization

Levels of estrogen and progesterone shift unevenly and unpredictably through perimenopause, causing hormonal symptoms, which include: Irregular periods and reduced fertility Hot flashes Insomnia Night sweats Changes in mood: depression, mood swings, and irritability Changes in sexual function: vaginal dryness and atrophy, painful intercourse, low libido, reduced sexual arousal, difficulty achieving orgasm Weight gain Breast tenderness Brain fog, forgetfulness, and difficulty concentrating (7, 30) Reductions in estrogen levels are also associated with increased risk for vaginal and urinary tract infections, osteopenia, osteoporosis, dyslipidemia, and heart disease (39)

With IV administration, the vitamins bypass the digestive system, allowing for higher absorption rates and delivering the vitamins directly into the bloodstream for immediate use by the body

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The stable, lyophilized powder is now a delicate liquid solution that is highly susceptible to degradation from heat and light